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Thursday

27-03-2025 Vol 19

DOGE FISHING ON HIS OWN CONDITIONS

The Trump administration has put its views on basic science. Last week, National Science Foundation revealed plan to dismiss between a neighborhood and half of its staff and the national institutes for health advertised That it would drastically reduce subsidies for university research programs. Meanwhile, Donald Trump has nominated the long -time NIH critic Robert F. Kennedy Jr. In order to operate the Institute for Health and Human Services, the Agency, which supervises much as 66 percent.

The cuts are eligible for efficiency. The change of NIH will chapter to administrative support – known as indirect costs or “overhead” – in 15 percent of direct financing. (Last night, a federal judge temporarily blocked NIH policy from going into effect – but only in the 22 states that defended to stop it.) The cord claims this will save the government more than $ 4 billion a year. Elon Musk whose department of government efficiency has been authorized by Executive Order To “maximize the effectiveness and productivity of the state” has already taken a victory meat. “Can you think that universities with tens of thousands of billions in gifts siphoned 60% of the research award money for ‘overhead’?” He wrote On X. “What Ripoff!”

Let’s devote the arguments of constitutional or wisdom by turning musk loose on federal bureaucracy. With his attack on research, Doge fails on its own terms. Cutting basic science funding violates its mandate to make the government more effective. If they survive Legal challengesThe movements may save money in the short term, but in the years and decades to come, the taxpayers cost expensive by slowing down innovation and making America’s future less prosperous.

Many breakthrough technologies began as very speculative, taxpayer-funded projects without any immediate practical value. The first computers were connected in 1969 through the Arpanet, a Department of Defense Funded Communications Network. Arpan’s narrow purpose at the time was to facilitate the sharing of expensive computer resources across project sites. In the 1980s, the NSF funded an expansion of the Arpanet concept to more than a dozen universities and eventually a nationwide network of supercomputing centers. This became the backbone of the modern internet when it was opened to commercial activity in the 1990s.

The practical value of a connected computer network became visible only before decades after the early ideas were financed. If DOGE had existed in the 1980s, cuts in the name of “efficiency” could have prevented or greatly delayed the development of one of the most important technologies in human history. Similarly, an NSF-funded project on the chopping block today may be on the field to lock future breakthroughs in pure energy or artificial intelligence.

Also in medicine, government financing of abstract seemingly useless research can lay the basis for transformative discoveries. To take only a recent example, the development of Ozempic and other GLP-1 weight loss medicine originated In NIH-funded research in reptiles. In the early 1980s, Jean-Pierre Raufman, a scientist who performed post-doctoral research at NIH, discovered that Gila-Monster Venom stimulated cell growth in the pancreas, the organ that synthesizes insulin. A few years later, Raufman and John Eng, an endocrinologist at a veteran’s affairs hospital discovered that the venom contained a peptide that stimulates insulin production much longer than the natural GLP-1 produced by the human body. Meadow patented the peptide and licensed the patent to amylin -araceutic drugs that Developed That as a diabetes treatment with NIH support. Twenty years later, pharmaceutical companies realized the revolutionary potential of the drug for weight loss.

Scientific discovery is unpredictable and random, with many surprises and dead ends. You can imagine a member of Congress in the 1980s condemning NIH’s wasting expenses for useless studies by Gila-Monster Venom. But Musk and his allies in Silicon Valley should know better. Like scientific research, venture capital is built to finance lots of ideas that go nowhere. Most venture capital investments fail, but the small number of wild successes make the whole company worth. These successes are difficult to predict because they can arise from seemingly outlandic new ideas, such as a virtual yearbook for college students.

The public has the right to demand that its tax dollar be used wisely. A good measure of the efficiency of public spending is whether it beats the Alternative: Returns the money to citizens as a tax relief.

Funding for basic research is effective of this very strict definition. Several studies have concluded that $ 1 spent on research typically returning More dollars value for society through increases in the private sectoral novation. Nearly one-third of NIH supplement over a 27-year period led to Publication of research that was eventually quoted in commercial patent applications and one in 10 NIH grants was quoted directly in a patent. A smart design study Estimated that an additional $ 10 million NIH financing generates about $ 23 million in the sale of newly patented drugs. And a working document, increased The annual patenting rate in the surrounding local economy by 18 to 32 percent. The overall picture is very consistent: Government financing of basic science research generates very large social returns, even when we cannot exactly predict the good ideas in advance.

This makes arbitrary cuts harmful and ineffective. Consider NIH’s proposal to limit university research funding. Government surveys provide funding for both direct costs – which means staff and material support, such as laboratory equipment, for specific projects – and indirect costs it calculates as a percentage of direct costs. Indirect costs finance the infrastructure that makes projects possible, including laboratory facilities, heating and electricity, finance and administration, data protection and compliance with the rules. In the announcement of the new policy, NIH said the average indirect grant in recent years was about 27 to 28 percent of direct financing.

The Trump administration claims that a 15 percent ceiling on indirect costs is reasonable because it is the rate typically paid by private funds. But Private-Foundation supplements can only be so low because of The existence of major government grants that support basic research infrastructure. Lowering the NIH rate to 15 percent will force universities to spend much more of their own money to support basic research. Even if rich private schools like Harvard, where I teach, can take a hit, most NIH funds go to cash-tape public universities without major endowments. If government financing disappears, much of the research will too. The long -term costs will be staggering. We have fewer medical breakthroughs, the progress of life -saving medical treatments will stop, and America may fall behind in its efforts to educate the next generation of major researchers and engineers.

There are many ways to make the state’s financing of scientific research more effective. It not -partisan institute of progress ordered a number of papers On how to improve NIH financing, including accelerated subsidy review, financing more risky but higher-up research and smoothing the way to commercialization. One could even lower the NIH costs by creating categories of grants with different indirect rates that depend on the scope and scope of the project. E.g. For example, justify may not really high cost. But the largest, most ambitious projects require significant investment of energy and space that a 15 percent rate will not begin to cover. DOGE should focus on these and other reforms rather than confuse the effectiveness of poorly imagined budget cuts that will make us sicker, poorer and less innovative in the coming years.

Littum